2008 University of Southern Mississippi Schedule/Results
| Date | Opponent | Location | TV | Time |
| 08/30/08 | Southern Miss 51, Louisiana-Lafayette 21 | Hattiesburg, Miss. | | |
| 09/06/08 | Auburn 27, Southern Miss 13 | Auburn, Ala. | Raycom | Gametracker |
| 09/13/08 | Southern Miss 27, Arkansas State 24 | Jonesboro, Ark. | | |
| 09/20/08 | Marshall 34, Southern Miss 27 | Hattiesburg, Miss. | CSS | |
| 10/04/08 | UTEP 40, Southern Miss 37 2OT | Hattiesburg, Miss. | MetroSports Southwest | |
| 10/11/08 | Boise State 24, Southern Miss 7 | Hattiesburg, Miss. | CBS College Sports Network | Gametracker | Watch |
| 10/18/08 | Rice 45, Southern Miss 40 | Houston, Texas | | Gametracker |
| 10/25/08 | Memphis 36, Southern Miss 30 | Memphis, Tenn. | CBS College Sports Network | Gametracker | Watch |
| 11/01/08 | Southern Miss 70, UAB 14 | Hattiesburg, Miss. | CSS | Gametracker |
| 11/08/08 | Southern Miss 17, UCF 6 | Orlando, Fla. | | Gametracker |
| 11/15/08 | Southern Miss 21, East Carolina 3 | Hattiesburg, Miss. | | Gametracker |
| 11/29/08 | Southern Miss 28, SMU 12 | Dallas, Texas | | Gametracker |
| 12/21/08 | Southern Miss 30, Troy 27 | New Orleans, La. | ESPN | Gametracker | Bowl Central |
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