The following is a list of active players from Conference USA schools are currently playing at the major league level.
| Player | Position | MLB Affiliation | C-USA School |
| Chad Tracy | 3B | Washington Nationals | East Carolina |
| Michael Bourn | OF | Free Agent | Houston |
| Jesse Crain | RHP | Chicago White Sox | Houston |
| Rob Johnson | C | St. Louis Cardinals | Houston |
| Donnie Joseph | LHP | Kansas City Royals | Houston |
| Brad Lincoln | RHP | Toronto Blue Jays | Houston |
| Garrett Mock | RHP | Arizona Diamondbacks | Houston |
| Chris Snyder | C | Free Agent | Houston |
| Dan Straily | RHP | Oakland Athletics | Marshall |
| Dan Uggla | 2B | Atlanta Braves | Memphis |
| David Aardsma | RHP | New York Yankees | Rice |
| Lance Berkman | OF | Texas Rangers | Rice |
| Tim Byrdak | LHP | New York Mets | Rice |
| Tony Cingrani | LHP | Cincinnati Reds | Rice |
| Brock Holt | IF | Boston Red Sox | Rice |
| Philip Humber | RHP | Houston Astros | Rice |
| Lucas Luetge | LHP | Seattle Mariners | Rice |
| Paul Janish | SS | Atlanta Braves | Rice |
| Jeff Niemann | RHP | Tampa Bay Rays | Rice |
| Lance Pendleton | RHP | Free Agent | Rice |
| Anthony Rendon | 3B | Washington Nationals | Rice |
| Joe Savery | LHP | Philadelphia Phillies | Rice |
| Brian Dozier | SS | Minnesota Twins | Southern Miss |
| Brian Bogusevic | OF | Chicago Cubs | Tulane |
| Brandon Gomes | RHP | Tampa Bay Rays | Tulane |
| Mark Hamilton | 1B | Boston Red Sox | Tulane |
| Tommy Manzella | SS | Colorado Rockies | Tulane |
| Micah Owings | RHP | San Diego Padres | Tulane |
| Josh Prince | OF | Milwaukee Brewers | Tulane |
| Drew Butera | C | Minnesota Twins | UCF |
| Beau Taylor | C | Oakland Athletics | UCF |
CONFERENCE USA PLAYERS IN MINOR LEAGUE BASEBALL
The following is a list of players that are playing professionally in the minor leagues. Teams listed are 2012 squads.
(as of Jan. 20, 2012)| Player | Pos. | Team | League | MLB Affiliation | C-USA School |
| Shawn Armstrong | P | Akron | Eastern (AA) | Cleveland | East Carolina |
| Kevin Brandt | P | Princeton | Appalachian (R) | Tampa Bay | East Carolina |
| Ricky Brooks | P | Colorado Springs | Pacific Coast (AAA) | Colorado | East Carolina |
| Jharel Cotton | P | Ogden | Pioneer (R) | LA Dodgers | East Carolina |
| Dustin Harrington | SS | Tennessee | Southern (AA) | Chicago Cubs | East Carolina |
| Devin Harris | OF | Fresno | Pacific Coast (AAA) | San Francisco | East Carolina |
| Chris Heston | P | Richmond | Eastern (AA) | San Francisco | East Carolina |
| Seth Maness | P | Springfield | Texas (AA) | St. Louis | East Carolina |
| Brad Mincey | P | Greensboro S | outh Atlantic (A) | Miami | East Carolina |
| Mark Minicozzi | 3B | Richmond | Eastern (AA) | San Francisco | East Carolina |
| Kyle Roller | DH | Tampa | Florida State (A) | NY Yankees | East Carolina |
| Seth Simmons | P | Visalia | California (A) | Arizona | East Carolina |
| Corey Thompson | 3B | Bristol | Appalachian ( R) | Chicago White Sox | East Carolina |
| John Wooten | 1B | Burlington | Midwest (A) | Oakland | East Carolina |
| Mike Wright | P | Bowie | Eastern (AA) | Baltimore | East Carolina |
| Zach Wright | C | Cedar Rapids | Midwest (A) | LA Dodgers | East Carolina |
| John Cannon | C | AZL Dodgers | Arizona ( R) | LA Dodgers | Houston |
| Jimmy Cesario | IF | Colorado Springs | Pacific Coast (AAA) | Colorado | Houston |
| Michael Goodnight | P | Carolina | Carolina (A) | Cleveland | Houston |
| Donnie Joseph | P | Omaha | Pacific Coast (AAA) | Kansas City | Houston |
| Blake Kelso | SS | Potomac | Carolina (A) | Washington | Houston |
| Ryan Lormand | 2B | Fresno | Pacific Coast (AAA) | San Francisco | Houston |
| Garrett Mock | P | Oklahoma City | Pacific Coast (AAA) | Houston | Houston |
| Wes Musick | P | Oklahoma City | Pacific Coast (AAA) | Houston | Houston |
| Bryan Pounds | IF | Toledo | International (AAA) | Detroit | Houston |
| Jared Ray | P | Missoula | Pioneer ( R) | Arizona | Houston |
| Caleb Ramsey | OF | Hagerstown | South Atlantic (A) | Washington | Houston |
| Chris Wallace | C | Oklahoma City | Pacific Coast (AAA) | Houston | Houston |
| Mo Wiley | P | Billings | Pioneer ( R) | Cincinnati | Houston |
| Steve Blevins | P | New Britain | Eastern (AA) | Minnesota | Marshall |
| Joe Church | P | Eugene | Northwest (A) | San Diego | Marshall |
| Jesse Fernandez | P | Aberdeen | N.Y. - Penn (A) | Baltimore | Marshall |
| Ian Kadish | P | Salt River | Arizona ( R) | Toronto | Marshall |
| Mike Mason | P | Grand Junction | Pioneer ( R) | Colorado | Marshall |
| Kevin Shackelford | P | Wisconsin | Midwest (A) | Milwaukee | Marshall |
| Arik Sikula | P | Vancouver | Northwest (A) | Toronto | Marshall |
| Kenny Socorro | IF | Peoria | Midwest (A) | Chicago Cubs | Marshall |
| Rhett Stafford | C/OF | Vermont | N.Y. - Penn (A) | Oakland | Marshall |
| Dan Straily | P | Sacramento | Pacific Coast (AAA) | Oakland | Marshall |
| Greg Williams | P | Myrtle Beach | Carolina (A) | Texas | Marshall |
| Brent Dlugach | SS | Toledo | International (AAA) | Detroit | Memphis |
| Jarrett Grube | P | Tacoma | Pacific Coast (AAA) | Seattle | Memphis |
| Derek Hankins | P | Round Rock | Pacific Coast (AAA) | Texas | Memphis |
| Dan Langfield | P | Billings | Pioneer ( R) | Cincinnati | Memphis |
| Drew Martinez | OF | Cedar Rapids | Midwest (A) | LA Angels | Memphis |
| Scott McGregor | P | Springfield | Texas (AA) | St. Louis | Memphis |
| Ben Paullus | P | Charleston | South Atlantic (A) | NY Yankees | Memphis |
| Neil Schenk | P | Montgomery | Southern (AA) | Tampa Bay | Memphis |
| Jacob Wilson | 3B | Batavia | N.Y. - Penn (A) | St. Louis | Memphis |
| Chad Zurcher | IF | Kingsport | Appalachian ( R) | NY Mets | Memphis |
| Andrew Benak | P | Staten Island | N.Y. Penn (A) | NY Yankees | Rice |
| Ryan Berry | P | Bowie | Eastern (AA) | Baltimore | Rice |
| J.T. Chargois | P | Elizabethtown | Appalachian ( R) | Minnesota | Rice |
| Tony Cingrani | P | Pensacola | Southern (AA) | Cincinnati | Rice |
| Jimmy Comerota | 3B | Mobile | Southern (AA) | Arizona | Rice |
| Tyler Duffey | P | Elizabethtown | Appalachian ( R) | Minnesota | Rice |
| Brian Friday | SS | Gwinnett | International (AAA) | Atlanta | Rice |
| Rick Hague | SS | Potomac | Carolina (A) | Washington | Rice |
| Tyler Henley | SS | Springfield | Texas (AA) | St. Louis | Rice |
| Brock Holt | 2B | Indianapolis | International (AAA) | Pittsburgh | Rice |
| Matt Langwell | P | Columbus | International (AAA) | Cleveland | Rice |
| Danny Lehmann | C | Rochester | International (AAA) | Minnesota | Rice |
| Aaron Luna | OF | Palm Beach | Florida State (A) | St. Louis | Rice |
| Craig Manuel | C | Auburn | N.Y. - Penn (A) | Washington | Rice |
| Chad Mozingo | OF | Schaumburg | Frontier | None | Rice |
| Mike Ojala | P | Jacksonville | Southern (AA) | Miami | Rice |
| Lance Pendleton | P | Durham | International (AAA) | Tampa Bay | Rice |
| Bryan Price | P | Columbus | International (AAA) | Cleveland | Rice |
| Jeremy Rathjen | OF | Ogden | Pioneer ( R) | LA Dodgers | Rice |
| Matthew Reckling | P | Ogden | Pioneer ( R) | LA Dodgers | Rice |
| Josh Rodriguez | IF | Binghampton | Eastern (AA) | New York Mets | Rice |
| Jared Rogers | P | GCL Marlins | Gulf Coast ( R) | Miami | Rice |
| Joe Savery | P/DH | Lehigh Valley | International (AAA) | Philadelphia | Rice |
| Cole St.Clair | P | Albuquerque | Pacific Coast (AAA) | LA Dodgers | Rice |
| Taylor Wall | P | Helena | Pioneer ( R) | Milwaukee | Rice |
| Jimmy Ballinger | P | Winston-Salem | Carolina (A) | Chicago White Sox | Southern Miss |
| Marc Bourgeois | OF | South Bend | Midwest (A) | Arizona | Southern Miss |
| Collin Cargill | P | Jacksonville | Southern (AA) | Miami | Southern Miss |
| Scott Copeland | P | Frederick | Carolina (A) | Baltimore | Southern Miss |
| Ashley Graeter | IF | Grand Junction | Pioneer ( R) | Colorado | Southern Miss |
| Jarrett Hoffpauir | IF | Syracuse | International (AAA) | Washington | Southern Miss |
| Brian Leach | P | Winnipeg | American Association | None | Southern Miss |
| B.A. Vollmuth | IF | Stockton | California (A) | Oakland | Southern Miss |
| Preston Claiborne | P | Scranton-Wilkes Barre | International (AAA) | NY Yankees | Tulane |
| Brad Emaus | 2B | Buffalo | International (AAA) | New York Mets | Tulane |
| Conrad Flynn | P | Reno | Pacific Coast (AAA) | Arizona | Tulane |
| Mark Hamilton | 1B | Memphis | International (AAA) | St. Louis | Tulane |
| Sam Honeck | 1B | Savannah | South Atlantic (A) | New York Mets | Tulane |
| Aaron Loup | P | New Hampshire | Eastern (AA) | Toronto | Tulane |
| Tommy Manzella | SS | Charlotte | International (AAA) | Chicago White Sox | Tulane |
| Josh Prince | OF | Huntsville | Southern (AA) | Milwaukee | Tulane |
| Taylor Rogers | P | San Jose | California (A) | San Francisco | Tulane |
| Anthony Scelfo | OF/IF | Laredo | American Association | None | Tulane |
| Jeremy Schaffer | C | Johnson City | Appalachian ( R) | St. Louis | Tulane |
| Rob Segedin | 3B | Trenton | Eastern (AA) | NY Yankees | Tulane |
| Josh Zeid | P | Corpus Christi | Texas (AA) | Houston | Tulane |
| Jamal Austin | OF | Clinton | Midwest (A) | Seattle | UAB |
| Nick Graffeo | P | Wilmington | Carolina (A) | Kansas City | UAB |
| Patrick Palmeiro | IF | Great Falls | Pioneer ( R) | Chicago White Sox | UAB |
| Ryan Woolley | P | Lakeland | Florida State (A) | Detroit | UAB |
| Tyson Auer | OF | Arkansas | Texas (AA) | LA Angels | UCF |
| Tim Bascom | P | Norfolk | International (AAA) | Baltimore | UCF |
| Chase Bradford | P | Savannah | South Atlantic (A) | NY Mets | UCF |
| Shane Brown | OF | Trenton | Eastern (AA) | NY Yankees | UCF |
| Nick Cicio | P | Southern Illinois | Frontier | None | UCF |
| Matt Collins | P | AZL Angels | Arizona ( R) | LA Angels | UCF |
| Chris Duffy | OF | Clearwater | Florida State (A) | Philadelphia | UCF |
| Matt Fox | P | Tacoma | Pacific Coast (AAA) | Seattle | UCF |
| Caleb Graham | P | Arkansas Texas | (AA) | LA Angels | UCF |
| Jonathan Griffin | IF | Mobile | Southern (AA) | Arizona | UCF |
| D.J. Hicks | 1B | Elizabethtown | Appalachian ( R) | Minnesota | UCF |
| Austin Hudson | P | High Desert | California (A) | Seattle Mariners | UCF |
| Robert Lara | C | San Antonio | Texas (AA) | San Diego | UCF |
| Derek Luciano | IF | Normal | Frontier | None | UCF |
| Roman Madrid | P | Eugene | Northwest (R) | San Diego | UCF |
| Ronnie Richardson | OF | Eugene | Northwest (R) | San Diego | UCF |
| Joe Rogers | P | Connecticut | N.Y.-Penn (A) | Detroit | UCF |
| Darnell Sweeney | SS | Great Lakes | Midwest (A) | LA Dodgers | UCF |
| Beau Taylor | C | Midland | Texas (AA) | Oakland | UCF |
